Psilocybin Retreat
Luxury All-Inclusive Psilocybin and DMT Retreat Program
The next level in psychedelic experiences.
August 3-10, 2025
August 15-18, 2025
August 31-September 7, 2025
Beyond Clinical Wellness
Psilocybin Retreat in Mexico
Experience a safe and immersive psychedelic journey, complete with expert guidance and medical support, at the only retreat offering a full-service med-spa, a mushroom cultivation workshop, and a DMT extraction class. Enjoy ultimate privacy in nature, combined with uncompromising luxury and comfort.
Sessions Completed
Private Retreat Center
For the Discerning Traveler
Empowerment Centered
We’ve developed an unparalleled program that places all the essential knowledge and skills directly in your hands. At our retreat, you’ll gain a deep understanding of how to use psychedelics to reach your personal goals, including how the medicine works and how it’s cultivated. We’re committed to demystifying the process and eliminating the gatekeeping often found in psychedelic circles, ensuring you’re set on the best path to success.

Individualized Dosing

Mycology and DMT Classes
The journey doesn’t end when the effects wear off. Our cultivation and extraction classes give you the practical skills to continue your healing journey, independently and with intention.
Continuous, consistent maintenance is often key to sustainable results. Since our inception, Eleusinia has focused on empowering you by placing the tools for success in your control.

Enhanced Medical Support
At Eleusinia, our US-trained medical team is fully integrated and on-site 24 hours for your convenience, comfort, and safety throughout every step of your psychedelic journey.
Our fully integrated team makes us uniquely poised to support each visitor, even those with more complex needs.

Beyond Mental Health
- Depression
- Anxiety
- OCD
- Body Dysmorphia
- Addiction
- Alcoholism
- Chronic Pain
- Migraine
- Cluster Headaches
- SUNCT/SUNA
- Hemicrania Continua
- NDPH
- Trigeminal Neuralgia
- Occipital Neuralgia
- Long Covid
- Autoimmune
- ME/CFS
- MS
- Parkinsons
- Post-Concussive S.
- Neuropathy
- Phanton Limb Pain

What Exactly Is A Neuroscience-Focused Psilocybin Retreat?
Eleusinia is a psilocybin retreat in Mexico that masterfully integrates modern research with a profound understanding of the effects of psychedelics on the brain. Here, you’ll encounter a unique blend of scientific rigor and consciousness exploration to unlock your full potential.
Psilocybin and DMT increase connectivity, communication, and synchrony between different brain regions. These remarkable substances serve as potent tools for elevating consciousness, deepening spirituality, and potentially shielding the brain and arteries from age-related illnesses like dementia and atherosclerosis. Additionally, they offer effective support for individuals managing chronic pain or mental health challenges by harnessing anti-inflammatory properties and promoting neuroplasticity.
In our retreats, we skillfully harmonize the worlds of science and tradition, ensuring you benefit from the best of both realms.
Eleusinia's Unique "Shuffle" Approach
At Eleusinia, we’ve developed a unique approach to psychedelics as a 'mental shuffle'—a guided process that breaks rigid mental patterns and reshapes perspectives. With expert facilitators, we ensure each experience is meaningful, safe, and deeply transformative.
Who visits Eleusinia?
Mental Reset
At Eleusinia, about 30% of guests arrive seeking a mental reset, whether it's for overcoming a professional rut, handling major life changes, improving relationships, or exploring their inner consciousness.
Psychological Wellness
Approximately 40% of Eleusinia visitors seek to improve mental health, inspired by promising psychedelic clinical trials for depression, OCD, and addiction.
Pain Management
Approximately 30% of Eleusinia visitors utilize our expertise in chronic pain management, harnessing the untapped potential of psychedelics for physical relief.
join us for our live virtual open house
Twice a month, as we prepare to welcome our next retreat guests, we open our virtual doors to you. It’s a casual, behind-the-scenes gathering where you can take a look around, meet the team, and ask anything you’re curious about. You’ll catch us in the moment- rolling out the red carpet, fluffing the pillows, and setting the tone for something meaningful. No script, no pressure- just a chance to connect and see if this place feels right for you.
Check the calendar below to see when the next open house is happening, sign up to get the link, and easily add it to your schedule. We’d love to see you there.
Retreat Reviews
bireshwarJune 16, 2025 The experience was magical, self-exploratory and spiritually awakening. Realizing there is more to life than life itself…Thanks to the beautiful ambience, amazing service, mouth watering food and the immense love and empathy of everyone working there. Jessica and Jay created an ultimate psilo experience. Jerry PriceMay 13, 2025 My experience at Eleusinia was something I will remember fondly for the rest of my life. The staff accepted us into their family and I accepted them into mine. My heart, mind and spirit will be forever grateful. James MenoMay 5, 2025 Having experimented with psilocybin as an adolescent and young adult, I viewed at it as something fun, scary, and most of all a powerful way to expand perspective. Now that I've been to Eleusinia, that hasn't changed haha! But, I would now add medicinal to my description of psychedelics. This experience was filled with uncomfortable moments for me, a lot happening in my head leading up to the experiences, and I don't think this is for everyone. The medicine was powerful; more than I ever experienced before. That said, IF you are ready or looking to shake up your life, this is for anyone. The staff and accommodations are outstanding. They will encourage you to explore and find the things you are there to work on, even if you don't know what they are. They guide without telling you what the exact path is, because it's different for everyone. They are there for you. Don't go with expectations, that's not how it works. If you are ready to let go a bit, this is the place. Not only through the medicine, but they take care of everything for you. I needed it, and I'm encouraged that these folks are genuinely helping people in a creative and unconventional way. Follow the love ;) Christa TApril 22, 2025 I recently attended a psilocybin mushroom retreat at Eleusinia, and the experience was nothing short of transformative. From the moment I arrived, there was a palpable sense of calm. The facilitators were experienced, deeply compassionate, and incredibly grounded. They provided an environment that felt not just safe, but sacred. Every aspect of the retreat was thoughtfully curated to support deep inner work. The psilocybin ceremony itself was guided with respect and reverence. Surrounded by nature, I was able to navigate profound emotional releases and an overwhelming sense of interconnectedness. Integration was a major focus of the retreat, and I appreciated how much attention was given to helping us bring our insights back into daily life, including one-on-one coaching. This retreat wasn’t just a psychedelic experience — it was a deep dive into healing, self-acceptance, and transformation. I can’t recommend it enough. Debbie LeeApril 6, 2025 I have been to Eleusinia twice and I plan to make this a return regularly. The staff, accommodations and the food is excellent. It is a life changing experience. Sergey AApril 2, 2025 It’s been seven months since I visited Eleusinia, and the amount of positive change I’ve been able to create in my life since then is unbelievable. It’s as if I’ve gained a new level of self-awareness, allowing me to see myself from an outside perspective and make meaningful improvements. The retreat itself is exceptional—a perfect setting for a profound, life-changing experience like psychedelics. The environment is peaceful and thoughtfully designed to put your mind at ease, allowing for deep introspection and transformation. The food was outstanding, the staff was incredibly attentive and supportive, and the accommodations were both luxurious and cozy, making the entire experience feel safe and comfortable. I’ve had many different experiences in my life, but this one stands out as one of the most impactful. I especially appreciated their science-based approach, free from any unnecessary mysticism or rituals. It’s a place where you can focus purely on your journey with confidence, knowing you are in the best hands. If you’re considering a retreat like this, I can’t recommend Eleusinia enough. Whether you’re looking for personal growth, healing, or just a new perspective on life, this is the ideal place to do it. It’s an experience that stays with you long after you leave, shaping your mindset in ways you never imagined. I’m deeply grateful for my time there, and I encourage anyone seeking meaningful change to take that step—you won’t regret it. Cierra JohnsJanuary 27, 2025 Eleusinia was an absolute life changing experience. The employees are all educated, dedicated, and loving people. The onsite medical team provided security and comfort. The thing I appreciated the most about this place was the people. People from all walks of life joined into one place to love and support people in their journeys. It’s truly a meaningful experience to be with incredible individuals and all the love they have to share. The atmosphere of Eleusinia was peaceful and welcoming. Everything is beautiful, clean, and updated. I felt so safe and taken care of. Last (but certainly not least)-the amazing food. It’s a vegetarian menu, which did come as a shock to me. Surprisingly, it was some of the most incredible dishes I’ve had! I love the variety and the fact that it’s still authentic. Amazing. I couldn’t recommend this place enough. Jenifer GarciaJanuary 27, 2025 My husband & I went to Eleusinia for the first time in November of 2023; and we're getting ready to go back for the FOURTH TIME so yes, you could say we're big fans of the Eleusinia experience & the positive impact it's made on both of our lives. We originally went due to my hubby's anxiety that had been hovering over his head like an ugly storm cloud for many, many years, tainting every good thing we had going on in our lives. It had gotten to an unmanageable level & he wished to solve the problem, not merely medicate the symptoms. I went along purely as a supportive spouse who had nothing to work on (laughable, looking back). ;) Learning how to macrodose in a controlled, perfect setting that Eleusinia creates was a huge gamechanger for us. They don't just aim for you to have a good retreat, they show you what to do to continue your work when you go back home so you can keep taking care of yourself. For me, I was a long-time migraine sufferer; they would strike without warning every 2-3 weeks & last 3-5 days every time, rendering me completely useless & absolutely miserable. With mushrooms (and actually ayahuasca as well but that's a different story), I have completely eradicated them & am now living a pain-free life in the head department. I will forever be grateful to Jessica & her crew for that alone. My husband is also in a much better place with his mental health now as well. And an interesting & unexpected additional benefit was the massive improvement in our 25 year marriage. Doing it alone would've been awesome, but doing it with your partner is even better if they're willing to have a little faith & go along for the ride. It has helped us to see our blind spots, create more empathy for each other & made us realize we had become a little "roommate-ish" over the years after raising kids, running businesses together, etc. That first macrodose alone was worth about 1,000 marriage counseling sessions! :) Over the years, we've both experienced many challenging trips as well as many pleasant ones & you know what? We got something positive out of every single one of them (sometimes even more in the challenging ones). Why do we keep coming back if it was so good the first time? Because we keep receiving benefit from doing it..and are always willing & able to go much deeper in the beautiful atmosphere Eleusinia has created than we would at home. Can't recommend this fabulous place enough! Troy ClarkJanuary 12, 2025 My wife and I have visited Eleusinia twice together and cannot express how wonderful each visit has been. Finding a Psilocybin retreat that could meet each of our needs individually was paramount. Having medical staff on site 24hrs was so comforting to us both. Being in recovery for several years from substance abuse and seeking out a Psilo retreat to help manage mental health in a foreign country was extremely scary. However, From the initial call with Jessica to leaving the 2nd retreat, I knew that we had made the correct choice. The whole experience with Eleusinia was life changing. The group breath work, Ice bath, macrodose sessions, DMT session, integration sessions and Mini dose sessions were all truly remarkable. The macrodose sessions were most impactful for me. Having the trained staff that I felt so comfortable around integrated into my experience was so beneficial. I was able to get vulnerable and express emotions in a way that I had never been able to accomplish in an office setting. I shared things with the team that I was never able to share with anyone without feeling judged. The team there is so kind and caring and go above and beyond in every way possible. Everyone at Eleusinia exceeded all expectations. We started each journey with random strangers and now we have a family. We will definitely be planning a 3rd visit when the timing is right.Google rating score: 4.9 of 5, based on 90 reviews
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Where elevated stays inspire sophisticated conversations and lasting connections.
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The Eleusinia Story
Jessica established Eleusinia, a psilocybin retreat in Mexico, after finding lasting relief from Hemicrania Continua - a debilitating headache condition - through psilocybin treatment. Located in Mexico, Eleusinia embodies her vision of an authentic cultural psychedelic retreat experience, blending the latest neuroscience with high standards for personalized care, comfortable accommodations, and balanced wellness support.
Want to hear real retreat stories from real guests? Check out our podcast with over 60 guest interviews detailing their experiences at our psilocybin retreat in Mexico.
We value your privacy
At Eleusinia Retreat, we are committed to protecting your privacy. To reflect the discretion we offer and the caliber of our guests, we maintain a firm no-photography policy and never share identifiable photos on social media.