Magnesium: A Key to Better Psychedelic Outcomes

Psychedelic experiences can sometimes be challenging. While set and setting are key factors in ensuring a positive journey, there may be other ways to promote a smoother and more productive experience. Glutamate is an essential neurotransmitter in the brain, and research suggests that improving glutamate regulation can enhance the quality of psychedelic experiences. Magnesium, a crucial nutrient, plays an important role in regulating glutamate activity. By acting as a natural blocker of NMDA receptors, which are activated by glutamate, magnesium helps prevent excessive activity, potentially fostering a more balanced and positive experience.

Glutamate and Negative Psychedelic Experiences

A 2020 study published in Nature explored the link between glutamate activity and negative experiences during psychedelic sessions. The research used advanced brain imaging techniques and found that psilocybin caused changes in glutamate levels within specific brain regions. Higher glutamate levels in the medial prefrontal cortex were linked to negative experiences, such as a distressing form of ego dissolution, while lower glutamate levels in the hippocampus were associated with more positive experiences of ego dissolution.

Understanding Challenging vs. Negative Experiences

It’s important to differentiate between challenging and negative psychedelic experiences. A difficult experience doesn’t necessarily mean it’s negative. Cathartic and intense experiences are often a part of personal growth, similar to the “hero’s journey” archetype. Many people approach psychedelic experiences with the intention of confronting and working through challenging aspects of their inner world.

However, it’s crucial to remain present during these moments. When anxiety or panic arises, it can interfere with our ability to engage fully with the experience, potentially limiting its benefits. Intense discomfort or fear may prevent us from embracing or subsequently even analyzing the experience, and this can reduce the therapeutic potential.

Harnessing Positive Intense Experiences

While some might assume that lower doses, such as micro-dosing, could reduce the likelihood of a challenging experience, research shows that profound therapeutic benefits are often associated with more intense experiences. These deeper experiences can lead to mystical insights and ego dissolution, both of which are key indicators of therapeutic success. Therefore, reducing the intensity of the experience may also reduce its healing potential.

At Eleusinia Retreat, we approach this differently from many centers in the industry. During the experience we address these challenges medically when necessary, using rescue medications to help participants relax into their experience. However, Magnesium’s role in glutamate regulation suggests that adequate supplementation prior to an experience may reduce the need for other types of intervention during the experience and help guests fully engage in their psychedelic sessions.

Challenges of Magnesium Supplementation

Although true magnesium deficiency (hypomagnesemia) is not well-documented, it is estimated that more than 65% of Americans do not meet the recommended daily intake of magnesium. Supplementation can be difficult, as certain forms of magnesium (like magnesium oxide) are poorly absorbed by the body, limiting their effectiveness. Additionally, high doses of magnesium can cause digestive issues such as diarrhea, nausea, and cramping. Striking the right balance is essential because improper levels of magnesium can affect other minerals like calcium and potassium.

We recommend starting a magnesium supplementation regimen before attending a retreat, ideally under the guidance of a healthcare provider to reach optimal levels at arrival. Oral supplementation takes time—typically a few weeks—to stabilize magnesium levels in the body.

IV Therapy at Eleusinia Retreat

For those seeking a faster approach, Eleusinia offers IV therapy treatments on-site that include magnesium. IV administration bypasses the digestive system, ensuring near-total absorption and providing a more efficient way to restore magnesium levels. This method is particularly effective for quickly correcting magnesium deficiencies, allowing guests to optimize their psychedelic experience.

Magnesium supplementation, when used thoughtfully, can be a helpful tool in creating a more balanced and meaningful psychedelic journey.

One Response

  1. I’m coming to the February 9-16 experience. Is there a magnesium supplement that you recommend I take prior to the experience?

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